Oricol
Our simple device for rectal mucosal sampling
Oricol™ is a simple medical device for collecting high-quality samples of the rectal mucosa in human subjects. This can then be analysed for extremely accurate diagnostics.
Simple
The collection procedure can be performed on any adult (subject to safety criteria) without the need for any type of bowel preparation or anaesthesia. It can be conducted by any clinical professional trained in proctoscopy.
Quick
The collection procedure takes just a few minutes. In many cases, health practitioners can discuss the procedure and take the sample all within the same appointment.
Painless
The procedure is safe, generally pain-free and has no side effects. The majority of patients find that it is far less unpleasant than the alternative, where they are required to take a sample of their stool.
Safe
The Oricol™ device is CE marked and the procedure is completely safe. The device has been successfully used on approaching 5,000 subjects worldwide with no adverse events reported – and very few reports of significant discomfort.
Effective
Oricol™ samples are at least 50,000 times richer in biomarkers than the leading alternative method, stool sampling. In addition, the potential to contaminate the sample is extremely low. This means that diagnostics based on Oricol™ samples are highly accurate.
Procedure
- The subject lies on their side, and a standard clinical proctoscope (disposable and included with the kit) is inserted into the rectum (a very common procedure).
- The device is then prepared and inserted into the proctoscope. A syringe is used to inject 80ml of air into the device.
- An elasticated membrane (balloon) is inflated against the rectal wall. The membrane is hydrophilic, attracting a thin layer of the rectal biofilm to its surface.
- After 10 seconds the membrane is retracted (back into the device), and the device removed from the proctoscope, which is then removed and disposed of.
- A stabilisation buffer is added to the sample (contained in a detachable component of the device), which is then sent to the laboratory for analysis.
- The remainder of the device and syringe is then disposed of according to local legislation.
Applications
Colorectal Cancer Diagnostics
We’re developing a colorectal cancer diagnostic test that analyses Oricol™ samples to provide a far more accurate diagnosis.
Other Applications
Origin Sciences continues to explore other ways of analysing Oricol™ samples to better diagnose and treat gastrointestinal disease.
Your Research
If you are conducting microbiome or gastrointestinal research, Oricol™ is an alternative to stool sampling that’s simpler and more effective. You can order Oricol™ devices directly from us.